The Shocking Story Of How The ONLY DEADLY Sweetener Was Approved By The FDA.

Aspartame.  It’s a name that you may have heard tossed around, especially in the 90’s.  It found its way into cereals, sodas, and all sorts of “sugar-free” products.  You may still encounter it in older packaged goods hanging around your grandparent’s or that weird little store on the corner.

So why is it something that we should be concerned about?  Aren’t there a hundred other ingredients that are on the list we should be paying attention to, instead?  Perhaps.  Perhaps not.

The true problem of aspartame, is that it has been banned by the FDA not once, but twice.  Then, it was allowed on the market, despite a mountain of scientific evidence that it wasn’t good for us, at all.  Definitely doesn’t sound like something worth taking a risk on, but because of the controversy, the official stance on the sugary-substitute is still unsure.  With a little bit of history, maybe you can decided for yourself whether it’s something you’d like in your body or not.

Accidentally discovered in the 1960’s by a company called G.D. Searle, it already had a bit of a shady beginning.  While trying to figure out a cure for stomach ulcers, a researcher for the company just so happened to make aspartame.  Thinking that it could possibly be a product worth its mettle, Searle put it through some more tests to see if it was viable.  These tests eventually lead to a review by the FDA, who decided it was safe enough to place on the market.  Not too long after, it became clear that aspartame wasn’t all it was cracked up to be.  Side effects, including a possible link to brain tumor growth, were discovered after three other independent studies were conducted on the sweetener.  This led to a 1977 criminal investigation into the apparently abominable research environment at Searle.  The FDA jumped into action, and decided to ban the product by 1980.

Shortly after, however, the chairman of Searle decided to try and reapply for aspartame approval.  This was in 1981, and there was an election going on.  Ronald Reagan stepped into office in 1982, and appointed a new commissioner of the FDA.  Arthur Hayes Hull, Jr. was his name, and he appointed a 5-person Scientific Commission to review the application.  The commission came to the conclusion that aspartame was no good, but Hull decided to add another person to the review, reaching a tie.  Then, Hull just went for it himself, and put aspartame back on the shelves.  Hull later resigned under fire for impropriety, as well as possible collusion, with corporations.  Indeed, Hull later went on to be a representative for both Monsanto and G.D. Searle.

Then what?  Well, after a few years, Monsanto decides to buy the patent for aspartame off of Searle.  This is 1985, and the debates over GMO’s and scientifically modified products is just beginning to heat up.  The problem is that Monsanto just doesn’t care.  It has continued, up to this day, to stand behind aspartame as a product worth producing.  Studies have piled up over the years that have shown that aspartame is possibly linked to a whole slew of health issues.  Essentially a nuerotoxin, it has been shown to cause leukemia, cancer, headaches, seizures, fibromyalgia, and epilepsy.  This is just a handful of the over 90 possible negative side effects of the sweetener.  It’s astonishing to how far this has gone, and that it hasn’t been pressed as a higher issue.

Below is a full rundown (borrowed from here) of how aspartame came to be, and the issues raised against it, over the years.  Decided for yourself if this evidence will persuade you in one direction or another.  Your health is in your hands, and your choices are yours alone.

December 1965– While working on an ulcer drug, James Schlatter, a chemist at G.D. Searle, accidentally discovers aspartame, a substance that is 180 times sweeter than sugar yet has no calories.

Spring 1967– Searle begins the safety tests on aspartame that are necessary for applying for FDA approval of food additives.

Fall 1967– Dr. Harold Waisman, a biochemist at the University of Wisconsin, conducts aspartame safety tests on infant monkeys on behalf of the Searle Company. Of the seven monkeys that were being fed aspartame mixed with milk, one dies and five others have grand mal seizures.

November 1970– Cyclamate, the reigning low-calorie artificial sweetener — is pulled off the market after some scientists associate it with cancer. Questions are also raised about safety of saccharin, the only other artificial sweetener on the market, leaving the field wide open for aspartame.

December 18, 1970– Searle Company executives lay out a “Food and Drug Sweetener Strategy’ that they feel will put the FDA into a positive frame of mind about aspartame. An internal policy memo describes psychological tactics the company should use to bring the FDA into a subconscious spirit of participation” with them on aspartame and get FDA regulators into the “habit of saying, “Yes”.”

Spring 1971– Neuroscientist Dr. John Olney (whose pioneering work with monosodium glutamate was responsible for having it removed from baby foods) informs Searle that his studies show that aspartic acid (one of the ingredients of aspartame) caused holes in the brains of infant mice. One of Searle’s own researchers confirmed Dr. Olney’s findings in a similar study.

February 1973– After spending tens of millions of dollars conducting safety tests, the G.D. Searle Company applies for FDA approval and submits over 100 studies they claim support aspartame’s safety.

March 5, 1973– One of the first FDA scientists to review the aspartame safety data states that “the information provided (by Searle) is inadequate to permit an evaluation of the potential toxicity of aspartame”. She says in her report that in order to be certain that aspartame is safe, further clinical tests are needed.

May 1974– Attorney, Jim Turner (consumer advocate who was instrumental in getting cyclamate taken off the market) meets with Searle representatives to discuss Dr. Olney’s 1971 study which showed that aspartic acid caused holes in the brains of infant mice.

July 26, 1974– The FDA grants aspartame its first approval for restricted use in dry foods.

August 1974– Jim Turner and Dr. John Olney file the first objections against aspartame’s approval.

March 24, 1976– Turner and Olney’s petition triggers an FDA investigation of the laboratory practices of aspartame’s manufacturer, G.D. Searle. The investigation finds Searle’s testing procedures shoddy, full of inaccuracies and “manipulated” test data. The investigators report they “had never seen anything as bad as Searle’s testing.”

January 10, 1977– The FDA formally requests the U.S. Attorney’s office to begin grand jury proceedings to investigate whether indictments should be filed against Searle for knowingly misrepresenting findings and “concealing material facts and making false statements” in aspartame safety tests. This is the first time in the FDA’s history that they request a criminal investigation of a manufacturer.

January 26, 1977– While the grand jury probe is underway, Sidley & Austin, the law firm representing Searle, begins job negotiations with the U.S. Attorney in charge of the investigation, Samuel Skinner.

March 8, 1977– G. D. Searle hires prominent Washington insider Donald Rumsfeld as the new CEO to try to turn the beleaguered company around. A former Member of Congress and Secretary of Defense in the Ford Administration, Rumsfeld brings in several of his Washington cronies as top management.

July 1, 1977– Samuel Skinner leaves the U.S. Attorney’s office and takes a job with Searle’s law firm. (see Jan. 26th)

August 1, 1977– The Bressler Report, compiled by FDA investigators and headed by Jerome Bressler, is released. The report finds that 98 of the 196 animals died during one of Searle’s studies and weren’t autopsied until later dates, in some cases over one year after death. Many other errors and inconsistencies are noted. For example, a rat was reported alive, then dead, then alive, then dead again; a mass, a uterine polyp, and ovarian neoplasms were found in animals but not reported or diagnosed in Searle’s reports.

December 8, 1977– U.S. Attorney Skinner’s withdrawal and resignation stalls the Searle grand jury investigation for so long that the statue of limitations on the aspartame charges runs out. The grand jury investigation is dropped.

June 1, 1979– The FDA established a Public Board of Inquiry (PBOI) to rule on safety issues surrounding NutraSweet.

September 30, 1980– The Public Board of Inquiry concludes NutraSweet should not be approved pending further investigations of brain tumors in animals. The board states it “has not been presented with proof of reasonable certainty that aspartame is safe for use as a food additive.”

January 1981– Donald Rumsfeld, CEO of Searle, states in a sales meeting that he is going to make a big push to get aspartame approved within the year. Rumsfeld says he will use his political pull in Washington, rather than scientific means, to make sure it gets approved.

January 21, 1981– Ronald Reagan is sworn in as President of the United States. Reagan’s transition team, which includes Donald Rumsfeld, CEO of G. D. Searle, hand picks Dr. Arthur Hull Hayes Jr. to be the new FDA Commissioner.

March, 1981– An FDA commissioner’s panel is established to review issues raised by the Public Board of Inquiry.

May 19, 1981– Three of six in-house FDA scientists who were responsible for reviewing the brain tumor issues, Dr. Robert Condon, Dr. Satya Dubey, and Dr. Douglas Park, advise against approval of NutraSweet, stating on the record that the Searle tests are unreliable and not adequate to determine the safety of aspartame.

July 15, 1981– In one of his first official acts, Dr. Arthur Hayes Jr., the new FDA commissioner, overrules the Public Board of Inquiry, ignores the recommendations of his own internal FDA team and approves NutraSweet for dry products. Hayes says that aspartame has been shown to be safe for its’ proposed uses and says few compounds have withstood such detailed testing and repeated close scrutiny.

October 15, 1982– The FDA announces that Searle has filed a petition that aspartame be approved as a sweetener in carbonated beverages and other liquids.

July 1, 1983– The National Soft Drink Association (NSDA) urges the FDA to delay approval of aspartame for carbonated beverages pending further testing because aspartame is very unstable in liquid form. When liquid aspartame is stored in temperatures above 85 degrees Fahrenheit, it breaks down into DKP and formaldehyde, both of which are known toxins.

July 8, 1983– The National Soft Drink Association drafts an objection to the final ruling which permits the use of aspartame in carbonated beverages and syrup bases and requests a hearing on the objections. The association says that Searle has not provided responsible certainty that aspartame and its’ degradation products are safe for use in soft drinks.

August 8, 1983– Consumer Attorney, Jim Turner of the Community Nutrition Institute and Dr. Woodrow Monte, Arizona State University’s Director of Food Science and Nutritional Laboratories, file suit with the FDA objecting to aspartame approval based on unresolved safety issues.

September, 1983– FDA Commissioner Hayes resigns under a cloud of controversy about his taking unauthorized rides aboard a General Foods jet. (General foods is a major customer of NutraSweet) Burson-Marsteller, Searle’s public relation firm (which also represented several of NutraSweet’s major users), immediately hires Hayes as senior scientific consultant.

Fall 1983– The first carbonated beverages containing aspartame are sold for public consumption.

November 1984– Center for Disease Control (CDC) “Evaluation of consumer complaints related to aspartame use.” (summary by B. Mullarkey)

November 3, 1987– U.S. hearing, “NutraSweet: Health and Safety Concerns,” Committee on Labor and Human Resources, Senator Howard Metzenbaum, chairman.

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